BioNMR Group

About us...

Structural dynamics singular features reveal new biological mechanisms. An integrated view of chemical and biological space. "Insanity: doing the same thing over and over again and expecting different results." (A. Einstein)

Publications

2023

- Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314 Bumbsak, F., Bower, J.B., Zemmer, S.C., Inoue, A., Pons, M., Paniagua, J.C., Yan, F., Ford, J., Wu, H., Robson, S.A., Bathgate, R.A.D., Scott, D.J., Gooley, P.R., Ziarek, J.J. Nature Communications, 14, 3328 (2023)

- Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1) Bumbak, F., Pons, M., Inoue, A., Paniagua, J.., Yan, F., Wu, H., Robson, S.A., Bathgate, R.A.D., Scott, D.J., Gooley, P.R., Ziarek, J.J. Cell Reports, 42, 112015 (2023)

- Lipid-mediated dimerization of membrane-anchored c-Src is driven by a cluster of lysine residues in the N-terminal SH4 domain Mohammad, L-I, Carvajal, J., Fernández, A., Taulés, M., Fourgous, E., Boublik, Y., Le Roux, A-L., Roche, S., Pons, M. bioRxiv 2022.05.31.494233; doi: https://doi.org/10.1101/2022.05.31.494233

- NMR approaches to study proteins integrating globular and disordered domains: the case of c- Src. Fernández, A., Lang, A., Gairí, M., González, M.T., Cárdenas, F., Pons, M., Pure and Applied Chemistry 2023; doi: https://doi.org/10.1515/pac-2022-1211

- Modulation of functional phosphorylation sites by basic residues in the Unique domain of c-Src Lang, A., Fernández, A., Diaz-Lobo, M., Vilanova, M., Cárdenas, F., Gairí, M., Pons, M., Molecules, 28, 4686 (2023)

- Targeting the Src N-terminal regulatory element in cancer Mezquita, B., Reyes-Farias, M., Pons, M. Oncotarget, 14, 503-513 (2023)

2022

- Regulation of Src tumor activity by its N-terminal intrinsically disordered region Aponte, E. Lafitte, M., Sirvent, A., Simon, V., Barbery, M., Oncogene, 41, 960-970 (2022)

- A FRET-Based Biosensor for the Src N-Terminal Regulatory Element Iruela, G., Fernández, A., Sagar, A., Carvajal, F.J., Bernadó, P., Pons, M Biosensors, 12(2), 96 (2022)

- Fuzzy Interactions: Many Facets of Protein Binding Piovesan, D., Arbesú, M., Fuxreiter, M., Pons, M. Frontiers Molecular Biosciences, 9, 947215 (2022)

- Frontiers of NMR Pons, M. J. Magn. Reson. Open, 12-13, 100071 (2022)

2021

- Basic Residue Clusters in Intrinsically Disordered Regions of Peripheral Membrane Proteins: Modulating 2D Diffusion on Cell Membranes. Pons, M. Physchem, 1, 152–162 (2021)

- A methionine chemical shift based order parameter characterizing global protein dynamics. Chasmniam, S., Teixeira, J.M.C,, Paniagua, JC, Pons, M. ChemBioChem, 22, 1001-1004 (2021).

- Synthesis and validation of DOPY: A new gemini dioleylbispyridinium based amphiphile for nucleic acid transfection Aubets, E., Greira, R., Félix, A.J., Rigol, G., Sikorski, C.C., Busquets, M.A., Pérez-García, L., Noé, V., Ciudad, C. European Journal of Pharmaceutics and Biopharmaceutics, 165, 279-292 (2021).

- Prussian Blue: A Nanozyme with Versatile Catalytic Properties Estelrich, J., Busquets, M.A. International Journal of Molecular Sciences, 22, 5993 (2021).

- Prussian Blue: A Safe Pigment with Zeolitic-Like Activity Estelrich, J., Busquets, M.A. International Journal of Molecular Sciences, 22, 780 (2021).

- Dual effect of prussian blue nanoparticles on Aβ40 aggregation: β-Sheet fibril reduction and copper dyshomeostasis regulation Kowalczyk, J., Grapsi, E., Espargaró, A., Caballero, A.B. Juárez-Jimenez, J., Busquets, M.A; Gamez, P., Sabate, R., Estelrich, J. Biomacromolecules, 22, 430 (2021).

2020

- Superparamagnetic nanoparticles with efficient near-infrared photothermal effect at the second biological window Busquets, M.A; Fernandez-Pradas, J.M.,Serra, P. Estelrich, J. Molecules, 25, 5315 (2020).

- Dual behavior of long-chain fatty acids and their cyclooxygenase/lipoxygenase metabolites on human intestinal caco-2 cell growth. Storniolo, C., Cabral, M., Busquets, M.A; Marti-Venegas, R., Moreno, J.J. Frontiers in Pharmacology, 11, 529976 (2020).

- Prussian blue nanoparticles: synthesis, surface modification, and biomedical applications. Busquets, M.A; Estelrich, J. Drug Discovery Today, 25, 1431-1443 (2020).

2019

- A myristoyl binding site in the SH3 domain modulates c-Src membrane anchoring Le Roux, A.L.; Mohammad, I.-L.; Mateos, B.; Arbesú, M.; Gairí, M.; Ali Khan, F.; Teixeira, J.M.C.; Pons, M. iScience , 12, 194-203 (2019).

- Cis-trans proline isomers in the catalytic domain of calcineurin Teixeira,J.M.C.; Guasch, A.; Biçer, A.; Aranguren-Ibáñez, A.; Chasmniam, S.; Paniagua, J.C.; Pérez-Riba, M.; Fita, I.; Pons, M. FEBS J. 286, 1230-1239 (2019)

- The disordered boundary of the cell: emerging properties of membrane-bound intrinsically disordered proteins. Mohammad, I-L, Mateos, B., Pons, M. BioMol Concepts, 10: 25-36 (2019)

- DNA specificities modulate the binding of human transcrition factor A to mitochondial DNA control region. Cuppari, A., Fernández-Millan, P., Battistini, F., Tarrés-Solé, A., Lyonnais, S., Iruela, G., Ruiz-López, E., Enciso, Y., Rubio-Cosials, A., Prohens, R., Pons, M. Alfonso, C., Tóth, K., Rivas, G., Orozco, M., Solà, M. Nucleic Acids Res. 47, 6519-6537 (2019)

- A “russian doll” approach to more efficient acquisition of IDP NMR spectra. Pons, M. Biophys. J., 117, 1-2 (2019)

- Integrating disorder in globular multidomain proteins: Fuzzy sensors and the role of SH3 domains. Arbesú, M., Pons, M. Archives Biochem Biophys, 677, 108161 (2019)

- Facile Synthesis of Novel Prussian Blue-Lipid Nanocomplexes. Busquets,M.A., Novella-Xicoy,A., Guzmán, V., Estelrich, J Molecules, 24(22), 4137 (2019)

2018

- The Two Isoforms of Lyn Display Different Intramolecular Fuzzy Complexes with the SH3 Domain Teixeira,J.M.C.; Fuentes, H.; Bielskute, S.; Gairi, M.; Zėrko,; Koźmiński, W.; Pons, M. Molecules, 23, 2731 (2018).

- Structure-based design of MptpB inhibitors that reduce multi-drug-resistant Mycobacterium tuberculosis survival and infection burden in vivo Vickers,C.; Silva, A.; Chakraborty, A.; Fernandez, P.; Kurepina, N.; Saville, C.; Naranjo, Y.; Pons, M.; Schnettger, L.; Gutierrez, M.; Park, S.; Kreiswirth, B.; Perlin, D.; Thomas, E.; Cavet, J.; Tabernero, L. J. Med. Chem., 61, 8337-8352 (2018)

- In cell NMR Mateos, B.; Maffei, M.; Pons, M. eLS a27152 (2018)

- Farseer-NMR: automatic treatment, analysis and plotting of large, multivariable NMR data Teixeira, J.M.C.; Skinner, S.P.; Arbesú, M.; Breeze, A.; Pons, M. Journal Biomolecular NMR, (2018)

- Intramolecular fuzzy interactions involving intrinsically disordered domains Arbesú, M.; Iruela, G.; Fuentes, H.; Teixeira, J.M.C.; Pons, M. Frontiers in Molecular Biosciences. (2018)

- All-trans-retinoic acid activated the pro-invasive Src-YAP-Interleukin 6 axis in triple-negative MDA-MB-231 breast cancer cells while cerivastatin reverses this action Mezquita, B.; Mezquita, P.; Pau, M.; Gasa, L.; Navarro, L.; Samitier, M.; Pons, M.; Mezquita, C. Scientific Reports, 8, 7047 (2018)

- Iron Oxide Nanoparticles in Photothermal Therapy. Estelrich, J., Busquet, M.A. Molecules. 23(7),1567 (2018)

2017

- The Unique domain forms a fuzzy intramolecular complex in Src family kinases Arbesú, M.; Maffei, M.; Cordeiro, T.N.; Teixeira, J.M.C.; Pérez,Y.; Bernadó, P.; Roche, S.;, Pons, M. Structure, 25, 630-640 (2017)

- NMR signal enhancement > 50000 times in Fast Dissolution Dynamic Nuclear Polarization Pinto, L F.; Marin-Montesinos, I.; Lloveras, V.; Muñoz-Gómez, J.L.; Pons, M.; Veciana, J.; Vidal-Gancedo, J. Chemical Communications, 53, 3757-3760 (2017)

- Evidence of Protein Adsorption in Pegylated Liposomes: Influence of Liposomal Decoration Sangra, M.; Estelrich, j.; Sabate, R.; Espargaro, A.; Busquets, M.A. Nanomaterials (Basel), 7, 37 (2017)

- Magnetic Nanoemulsions: Comparison between Nanoemulsions Formed by Ultrasonication and by Spontaneous Emulsification Rodriguez-Burneo, N,; Busquets, M.A.; Estelrich, J. Nanomaterials (Basel), 7, 190 (2017) )

2016

- An oxygen-sensitive toxin-antitoxin system Marimon, O; Teixeira, J.M.C.; Cordeiro, T.N.; Soo, V.W.C.; Wood, T.L.; Myzel, M.; Amata, I.; García, J.; Morera, A.; Gay, M.; Vilaseca, M.; Orekhov, V.Yu.; Wood, T.K.; Pons, M. Nature Communications, 2016 7: 13634 DOI 10.1038/ncomms13634

- A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125 Bijlmakers, M.J.; Teixeira, J.M.C.; Boer,R.; Mayzel, M.; Puig- Sàrries, P.; Karlsson, G.; Coll, M.; Pons, M. Crosas, B. Scientific Reports, 2016 6: 29232 DOI 10.1038/srep29232

- Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents Estelrich, .; Sánchez-Martín, M.J.; Busquets, M.A. Int. J. Nanomedicine, 10, 1727-1741 (2016)

- Single molecule fluorescence reveals dimerization of myristoylated Src N-terminal region on supported lipid bilayers Le Roux, A.L.; Castro, B.; Garbacik, E.T.; García Parajo, M.F.; Pons M. ChemistrySelect, 2016 4: 642-647.

- Kinetics characterization of c-Src binding to lipid membranes: Switching from labile to persistent binding Le Roux, A.-L.; Busquets, M.A.; Sagués, F.; Pons, M. Colloids and Surfaces B: Biointerfaces, 2016 138:17–25.

- N-lauroylation during the expression of recombinant N- myristoylated proteins. Implications and solutions. Flamm, A.G.: Le Roux, A.-L.; Mateos, B.; Díaz-Lobo, M.; Storch, B.; Breuker, K.; Konrat, R.; Pons, M.; Coudevylle, N. ChemBioChem, 2016 17:82-89.

- Paramagnetic spherical nanoparticles by the self-assembly of persistent trityl radicals. Marin-Montesinos, I.; Paniagua, J.C.; Peman, A.; Vilaseca, M.; Luis, F.; Van Doorslaer, S.; Pons, M. Physical Chemistry Chemical Physics 2016 18: 3151-3158. DOI 10.1039/c5cp05767a.

2015

- An intrinsically disordered region of RPN10 plays a key role in restricting ubiquitin chain elongation in RPN10 monoubiquitination Puig-Sàrries, P., Bijlmakers, M-J, Zuin, A., Bichmann, A. Pons, M. Crosas, B. Biochem. J. 2015 469:455–467.

- A Three-protein charge zipper stabilizes a protein complex modulating bacterial gene silencing Cordeiro, T.N., García, Bernadó, P., Millet, O., Pons, M. Journal Biological Chemistry 2015

- Improved stability and spectral quality in ex situ dissolution DNP using an improved transfer device. Katsikis, S., Marin-Montesinos, I Pons, M. Ludwig, C., Günther, U. Applied Magnetic Resonance 2015 46:723-729

- The SH3 Domain Acts as a Scaffold for the N-Terminal Intrinsically Disordered Regions of c-Src. Maffei M, Arbesú M, Le Roux AL, Amata I, Roche S, Pons M. Structure. 2015 23:893-902.

- Self-assembled trityl radical capsules--implications for dynamic nuclear polarization. Marin-Montesinos I, Paniagua JC, Vilaseca M, Urtizberea A, Luis F, Feliz M, Lin F, Van Doorslaer S, Pons M. Phys Chem Chem Phys. 2015 17:5785-94.

- Iron oxide nanoparticles for magnetically-guided and magnetically responsible drug delivery Estelrich, J.; Escribano, E.; Queralt, J.; Busquets, M.A. Int. J. Mol. Sci. 16, 8070-8101 (2015)

- An optimized method for 15N R1 relaxation rate measurements in non-deuterated proteins. Gairí M, Dyachenko A, González MT, Feliz M, Pons M, Giralt E J. Biomol. NMR 2015 DOI 10.1007/s10858-015-9937-4

2014

- Phosphorylation of unique domains of Src family kinases. Amata I, Maffei M, Pons M. Front Genet. 2014 5:181. doi: 10.3389/fgene.2014.00181

- Evidence for moonlighting functions of the θ subunit of Escherichia coli DNA polymerase III. Dietrich M, Pedró L, García J, Pons M, Hüttener M, Paytubi S, Madrid C, Juárez A. J Bacteriol. 2014 196(5):1102-12.

- The 13C solid DNP mechanisms with perchlorotriphenylmethyl radicals-the role of (35,37)Cl. Mentink Vigier F, Shimon D, Mugnaini V, Veciana J, Feintuch A, Pons M, Vega S, Goldfarb D. Phys Chem Chem Phys. 2014 16 :19218-28.

- Novel PTM-TEMPO biradical for fast dissolution dynamic nuclear polarization. Muñoz-Gómez JL, Marín-Montesinos I, Lloveras V, Pons M, Vidal-Gancedo J, Veciana J. Org Lett. 2014 16 :5402-5.

- Potential applications of magnetic particles to detect and treat Alzheimer’s disease Busquets, M.A.; Sabaté, R.; Estelrich, J. Nanoscale Research Letters, 9, 538 (2014)

2013

- Lipid binding by the unique and SH3 domains of c-Src suggests a new regulation mechanism. Perez Y, Maffei M, Igea A, Amata I, Gairí M, Nebreda AR, Bernadó P, Pons M. Scientific Reports 2013 3, 1295; DOI:10.1038/srep01295

- On the origin of the selectivity of plasmidic H-NS towards horizontally acquired DNA. Linking H-NS oligomerization and cooperative DNA binding. Fernandez-de-Alba C, Berrow NS, García-Castellanos R, García J, Pons M. Journal of Molecular Biology 2013 425:2347-2358

- Structural studies of the full-length self-assembled histone-like nucleoid structuring protein (H-NS) using solid-state NMR spectroscopy. Renault M, García J, Cordeiro T, Baldus M, Pons M. FEBS J. 2013 280:2916-2928

- Multi-phosphorylation of the intrinsically disordered unique domain of c-Src studied by in-cell and real-time NMR. Amata I, Maffei M, Igea A, Gay, M, Vilaseca M, Nebreda AR, Pons M. ChemBioChem 2013 14:1820-1827

- Long-lived states in an intrinsically disordered protein domain Fernandes L, Guerniou C, Marín-Montesinos I, Pons M, Kateb F, Vasos PR. Magn. Reson. Chem. 2013 51: 729–733

2012

- Oligomerization and DNA binding of Ler, a master regulator of pathogenicity of enterohemorrhagic and enteropathogenic Escherichia coli. García J, Cordeiro TN, Prieto MJ, Pons M. Nucleic Acids Res. 2012 Nov 1;40(20):10254-62.

- Meta-structure correlation in protein space unveils different selection rules for folded and intrinsically disordered proteins Naranjo Y, Pons M, Konrat R. Molecular BioSystems 2012 8: 411-416

2011

- Protein loop compaction and the origin of the effect of arginine and glutamic acid mixtures on solubility, stability and transient oligomerization of proteins. Blobel J, Brath U, Bernadó P, Diehl C, Ballester L, Sornosa A, Akke M, Pons M. Eur Biophys J. 2011 Dec;40(12):1327-38.

- Indirect DNA readout by an H-NS related protein: structure of the DNA complex of the C-terminal domain of Ler. Cordeiro TN, Schmidt H, Madrid C, Juárez A, Bernadó P, Griesinger C, García J, Pons M. PLoS Pathog. 2011 Nov;7(11):e1002380.

- Correlation of the EPR properties of perchlorotriphenylmethyl radicals and their efficiency as DNP polarizers. Banerjee D, Paniagua JC, Mugnaini V, Veciana J, Feintuch A, Pons M, Goldfarb D. Phys Chem Chem Phys. 2011 Nov 7;13(41):18626-37.

2010

- Dynamic nuclear polarization with polychlorotriphenylmethyl radicals: supramolecular polarization-transfer effects. Gabellieri C, Mugnaini V, Paniagua JC, Roques N, Oliveros M, Feliz M, Veciana J, Pons M. Angew Chem Int Ed Engl. 2010 Apr 26;49(19):3360-2.

- Polychlorinated trityl radicals for dynamic nuclear polarization: the role of chlorine nuclei. Paniagua JC, Mugnaini V, Gabellieri C, Feliz M, Roques N, Veciana J, Pons M. Phys Chem Chem Phys. 2010 Jun 14;12(22):5824-9.

- Structuring Chemical Space: Similarity-Based Characterization of the PubChem Database Cincilla G, Thormann M, Pons M. Mol. Inf. 29, 37-49 (2010) DOI: 10.1002/minf.200900015.

2009

- Structural characterization of the natively unfolded N-terminal domain of human c-Src kinase: insights into the role of phosphorylation of the unique domain. Pérez Y, Gairí M, Pons M, Bernadó P. J. Mol. Biol., 391, 136-148 (2009).

- Low-resolution structures of transient protein-protein complexes using small-angle X-ray scattering. Blobel J, Bernadó P, Svergun DI, Tauler R, Pons M. J Am Chem Soc. 2009 Apr 1;131(12):4378-86.

- Weak oligomerization of low-molecular-weight protein tyrosine phosphatase is conserved from mammals to bacteria. Blobel J, Bernadó P, Xu H, Jin C, Pons M. FEBS J. 2009 Aug;276(16):4346-57.

2008

- Structural characterization of the active and inactive states of Src kinase in solution by small-angle X-ray scattering. Bernadó P, Pérez Y, Svergun DI, Pons M. J Mol Biol. 2008 Feb 15;376(2):492-505.

2007

- Nomen Est Omen: Quantitative Prediction of Molecular Properties Directly from IUPAC Name. Thormann M, Vidal D, Almstetter M, Pons M. The Open Applied Informatics Journal 01/2007; 107:28-32.

- Protein tyrosine phosphatase oligomerization studied by a combination of 15N NMR relaxation and 129Xe NMR. Effect of buffer containing arginine and glutamic acid. Blobel J, Schmidl S, Vidal D, Nisius L, Bernadó P, Millet O, Brunner E, Pons M. J Am Chem Soc. 2007 May 9;129(18):5946-53.

- Structure-based discovery of new small molecule inhibitors of low molecular weight protein tyrosine phosphatase. Vidal D, Blobel J, Pérez Y, Thormann M, Pons M. Eur J Med Chem. 2007 Aug;42(8):1102-8.

2006

- A novel search engine for virtual screening of very large databases. Vidal D, Thormann M, Pons M. J Chem Inf Model. 2006 Mar-Apr;46(2):836-43.

- Fast 2D NMR ligand screening using Hadamard spectroscopy. Feliz M, García J, Aragón E, Pons M. J Am Chem Soc. 2006 Jun 7;128(22):7146-7.

2005

- LINGO, an efficient holographic text based method to calculate biophysical properties and intermolecular similarities. Vidal D, Thormann M, Pons M. J Chem Inf Model. 2005 Mar-Apr;45(2):386-93.

2003

- Combined use of NMR relaxation measurements and hydrodynamic calculations to study protein association. Evidence for tetramers of low molecular weight protein tyrosine phosphatase in solution. Bernadó P, Akerud T, García de la Torre J, Akke M, Pons M. J Am Chem Soc. 2003 Jan 29;125(4):916-23.

2002

- Interpretation of 15N NMR relaxation data of globular proteins using hydrodynamic calculations with HYDRONMR. Bernadó P, García de la Torre J, Pons M. J Biomol NMR. 2002 Jun;23(2):139-50.

- Lanthanide modulation of the orientation of macromolecules induced by purple membrane. Bernadó P, Barbieri R, Padrós E, Luchinat C, Pons M. J Am Chem Soc. 2002 Jan 23;124(3):374-5.